Humanin from Super Human Peptides UK is a naturally occurring, 24-amino acid mitochondrial-derived peptide (MDP). It was originally discovered in the surviving brain tissue of subjects in Alzheimer's disease models. Unlike traditional nuclear-encoded proteins, Humanin is encoded entirely within the mitochondrial genome (specifically the 16S ribosomal RNA gene).
In laboratory research, Humanin is renowned for its profound cytoprotective, neuroprotective, and anti-apoptotic (cell-death preventing) properties. Researchers utilize this peptide to study cellular resilience against oxidative stress, mitochondrial dysfunction, and the accumulation of toxic proteins like amyloid-beta. Produced under GMP-compliant conditions and verified for 99% purity or higher, Humanin offers a highly specialized model for investigating age-related cellular degeneration and mitochondrial signalling.
- —Mitochondrial Origin: An endogenous mitochondrial-derived peptide (MDP).
- —Anti-Apoptotic: Studied for its ability to bind and neutralize pro-apoptotic proteins.
- —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
- —Quality Standard: GMP / ISO certified manufacturing.
- —Documentation: Full Certificate of Analysis (COA) provided with every batch.
- —Apoptosis Inhibition: Studies on the physical interaction between Humanin and the BAX protein to prevent mitochondrial cell death pathways.
- —Neurodegenerative Models: Research investigating the peptide's ability to protect neurons from amyloid-beta and tau protein toxicity.
- —Oxidative Stress: Preclinical modelling of cellular defense mechanisms against reactive oxygen species (ROS) and hypoxia.
- —Cardiovascular Protection: Studies on endothelial cell survival and the reduction of atherosclerotic plaque formation under metabolic stress.
- —Retrograde Signalling: Investigating how mitochondria communicate with the nucleus to regulate cellular energy balance and systemic homeostasis.
Humanin has sparked an entirely new field of research focused on mitochondrial-derived peptides functioning as cellular guardians. Hashimoto et al. (2001) first identified Humanin's ability to suppress neuronal cell death in Alzheimer's disease models.
Subsequent laboratory studies have revealed that Humanin acts by directly binding to BAX, preventing it from migrating to the mitochondria and triggering the release of cytochrome c, thereby halting the apoptotic cascade. Beyond neurobiology, animal models have demonstrated Humanin's broad cytoprotective effects in cardiovascular and metabolic research. It has been shown to improve endothelial function, reduce systemic inflammatory markers, and even increase mitochondrial ATP production.
Because endogenous Humanin levels decline significantly with age, it is a primary subject of study in gerontology for its potential to restore cellular resilience in aged tissues.
- 1.Hashimoto, Y. et al., "A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta," Proceedings of the National Academy of Sciences, 2001.
- 2.Guo, B. et al., "Humanin peptide suppresses apoptosis by interfering with Bax activation," Nature, 2003.
- 3.Lee, C. et al., "The mitochondrial-derived peptide humanin protects against oxidative stress and aging," Aging Cell, 2014.
- 4.Muzumdar, R.H. et al., "Humanin: a novel central regulator of peripheral insulin action," PLoS One, 2009.
