5-AMINO-1MQ
5-AMINO-1MQ

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5-AMINO-1MQ

5-AMINO-1MQ
5-AMINO-1MQ
5-AMINO-1MQ
5-AMINO-1MQ
5-AMINO-1MQ
5-AMINO-1MQ

5-AMINO-1MQ

£16.00Sold out
Out of stock
Size
1
ABOUT THIS COMPOUND
Description

5-Amino-1MQ from Super Human Peptides UK is a highly advanced, synthetic small molecule. Unlike traditional incretin mimetics or appetite suppressants, it operates completely independent of the central nervous system and hormonal satiety pathways. In laboratory research, 5-Amino-1MQ is revered as a potent, highly selective inhibitor of the Nicotinamide N-methyltransferase (NNMT) enzyme.

As bodies age or accumulate excess fat, NNMT becomes overexpressed in white adipose tissue, acting as a metabolic sink that drains the body's reserves of NAD+ (Nicotinamide Adenine Dinucleotide). By pharmacologically blocking the NNMT enzyme, 5-Amino-1MQ prevents this drain, causing a massive intracellular surge of NAD+. This surge drastically accelerates cellular metabolism, forcing white fat cells to shrink and burn oxidized fatty acids for energy.

Produced under GMP-compliant conditions and verified for 99% purity or higher, 5-Amino-1MQ is a premier model for investigating the reversal of diet-induced obesity, metabolic syndrome, and cellular senescence.

WarningFor laboratory research use only. Not for human consumption.
Key Features
  • —NNMT Inhibitor: Specifically targets and blocks the Nicotinamide N-methyltransferase enzyme overexpressed in aging and obese adipose tissue.
  • —NAD+ Amplifier: Directly increases intracellular NAD+ levels by preventing its enzymatic degradation, effectively reversing cellular metabolic aging.
  • —Targeted Lipolysis: Shrinks white adipose tissue by accelerating basal metabolic burn rather than merely suppressing caloric intake.
  • —Muscle Stem Cell Rejuvenation: Studied for its secondary ability to activate muscle satellite cells, promoting rapid recovery and preventing age-related sarcopenia.
  • —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
  • —Quality Standard: GMP / ISO certified manufacturing.
Research Focus
  • —Enzyme Kinetics: Studying the highly specific, competitive binding of the small molecule to the active site of the NNMT enzyme.
  • —Diet-Induced Obesity: Preclinical models exploring the rapid, sustained reduction of body mass and white fat volume in subjects fed a high-fat diet, without any reduction in food consumption.
  • —NAD+ Salvage Pathway: Measuring the downstream up-regulation of SIRT1 and SIRT3 (longevity proteins) triggered by the restoration of cellular NAD+ levels.
  • —Muscle Regeneration: Investigating the proliferation of aged muscle stem cells (satellite cells) and the restoration of contractile force following chemically induced tissue injury.
  • —Lipid Profile Modulation: Evaluating the clearance of hepatic triglycerides and the normalization of circulating cholesterol profiles driven by enhanced cellular respiration.
Published Research and Study Findings

The development of 5-Amino-1MQ represents a massive breakthrough in metabolic research, heavily pioneered by Dr. Stanley Watowich and his team at the University of Texas Medical Branch (UTMB). The researchers identified that NNMT acts as the body's metabolic "brakes," slowing down fat-burning to preserve energy as organisms accumulate adipose tissue.

In their landmark laboratory studies, administration of 5-Amino-1MQ to diet-induced obese animal models yielded astonishing results. Within just 11 days, subjects exhibited a 30% decrease in white adipose tissue mass and a 7% reduction in total body weight—all while showing no changes in food intake or physical activity levels. Furthermore, subsequent studies on aged models revealed that blocking NNMT restores the regenerative capacity of senescent muscle tissue, essentially tricking the cells into acting biologically younger.

Because it safely un-couples metabolism from caloric restriction, it is widely considered one of the most promising small molecules in modern gerontological and anti-obesity research.

NoteAll findings are derived from laboratory and non-clinical research settings.
Representative Scientific References
  • 1.Neelakantan, H. et al., "Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle," Biochemical Pharmacology, 2019.
  • 2.Neelakantan, H. et al., "Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice," Biochemical Pharmacology, 2018.
  • 3.Stromsdorfer, K.L. et al., "Targeted depletion of nicotinamide N-methyltransferase (NNMT) protects against diet-induced obesity," Nature Chemical Biology, 2013. (Contextual NNMT mechanisms).
  • 4.Watowich, S.J. et al., "Nicotinamide N-methyltransferase inhibition as a novel therapeutic strategy for obesity and metabolic disorders," Expert Opinion on Therapeutic Targets, 2020.
Technical data
Specifications
Purity
≥99%, HPLC verified
Form
Lyophilised white powder
Molecular formula
C10H11IN2
Molecular weight
302.11 g/mol
SKU
SHP-5AMINO-05
Research category
Metabolic
Storage
-20°C, protected from light
Reconstitution
Reconstitute with bacteriostatic water; swirl gently, do not shake
Research use
In-vitro laboratory research only. Not for human consumption.
Common questions
Frequently asked questions
5-AMINO-1MQ is a synthetic small molecule that acts as a potent, highly selective inhibitor of the nicotinamide N-methyltransferase (NNMT) enzyme. It is supplied lyophilised at ≥99% purity.
It is studied in enzyme kinetics work, obesity models and muscle regeneration research, particularly where the aim is to raise cellular NAD+ availability by blocking its consumption.
5-AMINO-1MQ is supplied at ≥99% purity, verified by HPLC with mass-spectrometry identity confirmation. Testing is carried out per batch rather than per product line, so the figures on your certificate of analysis relate to the exact lot in your vial.
Store the sealed vial at -20°C, protected from light. Once reconstituted, the solution should be kept refrigerated at 2-8°C, protected from light, and treated as a short-lived working preparation rather than a long-term stock.
5-AMINO-1MQ is supplied lyophilised. Reconstitute with bacteriostatic water; swirl gently, do not shake, and allow the powder to dissolve fully before use. Direct the solvent down the inside wall of the vial rather than onto the pellet, and record the volume used so working concentrations can be calculated. This applies to in-vitro laboratory work only.
NAD+ supplies the coenzyme directly; 5-AMINO-1MQ raises it indirectly by inhibiting the enzyme that depletes its precursor. Studies comparing direct supply against enzymatic conservation as strategies for elevating NAD+ often use the two together as contrasting arms.
Yes. A certificate of analysis covering HPLC purity and mass-spectrometry identity is available for every batch of 5-AMINO-1MQ. Each vial carries a batch number on its label, and quoting that number lets us send you the certificate that matches the material you hold rather than a generic example.
5-AMINO-1MQ has the molecular formula C10H11IN2 and a molecular weight of 302.11 g/mol. Those figures are stated on the certificate of analysis supplied with each batch and are the values researchers use when preparing molar calculations.
5-AMINO-1MQ ships from the UK to UK research addresses, with tracked dispatch and insulated packaging. It is sold for in-vitro laboratory research only: it is not a medicine, not a supplement, and not for human or veterinary consumption. Orders are accepted on the basis that the buyer is a qualified researcher.