ACTH (1-39)
ACTH (1-39)

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ACTH (1-39)

ACTH (1-39)
ACTH (1-39)
ACTH (1-39)
ACTH (1-39)
ACTH (1-39)
ACTH (1-39)

ACTH (1-39)

£24.00Sold out
Out of stock
Size
1
ABOUT THIS COMPOUND
Description

ACTH (1-39) from Super Human Peptides UK is the full-length, 39-amino acid synthetic analogue of human Adrenocorticotropic Hormone. Endogenously produced and secreted by the anterior pituitary gland, it is the primary biological driver of the body’s systemic stress response. In laboratory research, ACTH (1-39) is the foundational model for investigating the Hypothalamic-Pituitary-Adrenal (HPA) axis.

Unlike truncated cognitive fragments (such as ACTH 4-10 or Semax), the full 1-39 sequence is required to bind specifically to the Melanocortin 2 Receptor (MC2R) located on the adrenal cortex. Researchers utilize this full-length peptide to study the direct pharmacological stimulation of the adrenal glands, resulting in the secretion of glucocorticoids (like cortisol) and mineralocorticoids. Produced under GMP-compliant conditions and verified for 99% purity or higher, ACTH (1-39) is a critical tool for advanced research into adrenal insufficiency, systemic stress-response pathways, and complex neuroendocrine feedback loops.

WarningFor laboratory research use only. Not for human consumption.
Key Features
  • —Full-Length Sequence: The complete 39-amino acid chain identical to endogenous human ACTH.
  • —HPA Axis Modulator: The master regulator of the hypothalamic-pituitary-adrenal stress pathway.
  • —MC2R Specificity: Specifically binds to the Melanocortin 2 Receptor to trigger adrenal steroidogenesis.
  • —Systemic Application: Utilized to test full adrenal capacity rather than isolated neurological effects.
  • —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
  • —Quality Standard: GMP / ISO certified manufacturing.
Research Focus
  • —Adrenal Steroidogenesis: Studying the intracellular signaling pathways that convert cholesterol into active glucocorticoids following MC2R activation.
  • —HPA Axis Integrity: Preclinical models utilizing ACTH challenge tests to measure adrenal reserve and identify secondary vs. primary adrenal insufficiency.
  • —Circadian Rhythms: Investigating the peptide's role in the naturally occurring "cortisol awakening response" and physiological synchronization.
  • —Stress Response Pathways: Researching the systemic metabolic adaptations (such as lipolysis and glycogenolysis) triggered by profound, acute ACTH surges.
  • —Melanocortin Receptor Mapping: Evaluating the binding affinity and cross-reactivity of the full-length peptide across all five known melanocortin receptors (MC1R-MC5R).
Published Research and Study Findings

ACTH was one of the earliest polypeptide hormones to be fully sequenced, fundamentally shaping our modern understanding of endocrinology. Landmark laboratory studies demonstrated that the first 24 amino acids (ACTH 1-24) contain the primary biological activity, but the full 1-39 sequence provides the extreme stability and precise receptor specificity seen in natural biological systems. In laboratory settings, administering ACTH (1-39) induces a rapid, dose-dependent release of corticosteroids from the adrenal cortex.

Because it bypasses the hypothalamus and directly targets the adrenal glands, it is the universal gold standard for testing adrenal function. Animal models treated with full-length ACTH exhibit profound metabolic shifts necessary for survival under acute stress, including elevated blood glucose, immune system modulation, and profound anti-inflammatory cascades. Due to its systemic power, it is strictly utilized to map the upper limits of endocrine capacity and severe stress-adaptation mechanisms.

NoteAll findings are derived from laboratory and non-clinical research settings.
Technical data
Specifications
Purity
≥99%, HPLC verified
Form
Lyophilised white powder
Molecular formula
C207H308N56O58S
Molecular weight
4541.1 g/mol
Sequence
39 amino acids (full-length ACTH)
SKU
SHP-ACTH-039
Research category
Cognitive
Storage
-20°C, protected from light
Reconstitution
Reconstitute with bacteriostatic water; swirl gently, do not shake
Research use
In-vitro laboratory research only. Not for human consumption.
Common questions
Frequently asked questions
ACTH (1-39) is a full-length 39-amino-acid synthetic analogue of human adrenocorticotropic hormone that binds the melanocortin 2 receptor on the adrenal cortex. Purity is ≥99% or higher.
It is designed for research into the hypothalamic-pituitary-adrenal axis and adrenal function, covering steroidogenesis, HPA axis integrity, circadian rhythm, stress response pathways and melanocortin receptor mapping.
ACTH (1-39) is supplied at ≥99% purity, verified by HPLC with mass-spectrometry identity confirmation. Testing is carried out per batch rather than per product line, so the figures on your certificate of analysis relate to the exact lot in your vial.
Store the sealed vial at -20°C, protected from light. Once reconstituted, the solution should be kept refrigerated at 2-8°C, protected from light, and treated as a short-lived working preparation rather than a long-term stock.
ACTH (1-39) is supplied lyophilised. Reconstitute with bacteriostatic water; swirl gently, do not shake, and allow the powder to dissolve fully before use. Direct the solvent down the inside wall of the vial rather than onto the pellet, and record the volume used so working concentrations can be calculated. This applies to in-vitro laboratory work only.
Semax is an analogue of the ACTH 4-10 fragment, retained for its neurotrophic activity while the hormonal signalling of the full molecule is left behind. ACTH (1-39) is the complete sequence and is used where adrenal and HPA axis endocrinology is the object of study rather than cognition.
Yes. A certificate of analysis covering HPLC purity and mass-spectrometry identity is available for every batch of ACTH (1-39). Each vial carries a batch number on its label, and quoting that number lets us send you the certificate that matches the material you hold rather than a generic example.
ACTH (1-39) has the molecular formula C207H308N56O58S and a molecular weight of 4541.1 g/mol. Those figures are stated on the certificate of analysis supplied with each batch and are the values researchers use when preparing molar calculations.
ACTH (1-39) ships from the UK to UK research addresses, with tracked dispatch and insulated packaging. It is sold for in-vitro laboratory research only: it is not a medicine, not a supplement, and not for human or veterinary consumption. Orders are accepted on the basis that the buyer is a qualified researcher.