Kisspeptin-10
Kisspeptin-10

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Kisspeptin-10

Kisspeptin-10
Kisspeptin-10
Kisspeptin-10
Kisspeptin-10
Kisspeptin-10
Kisspeptin-10

Kisspeptin-10

£26.00Sold out
Out of stock
Size
1
ABOUT THIS COMPOUND
Description

Kisspeptin-10 from Super Human Peptides UK is a highly potent synthetic decapeptide derived from the KISS1 gene. It is the primary endogenous ligand for the GPR54 (KISS1R) receptor. In laboratory research, Kisspeptin-10 is recognized as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis.

Researchers utilize this peptide to study the upstream stimulation of Gonadotropin-Releasing Hormone (GnRH), which subsequently triggers the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Produced under GMP-compliant conditions and verified for 99% purity or higher, Kisspeptin-10 is a critical tool for neuroendocrine studies, fertility modelling, and research into reproductive hormone pulsatility.

WarningFor laboratory research use only. Not for human consumption.
Key Features
  • —Master HPG Regulator: Primary agonist for the GPR54 receptor.
  • —Upstream GnRH Modulator: Stimulates the natural pulsatile release of LH and FSH.
  • —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
  • —Quality Standard: GMP / ISO certified manufacturing.
Research Focus
  • —HPG Axis Modulation: Studying the upstream regulation of the reproductive endocrine system.
  • —GnRH Pulsatility: Researching the induction of Gonadotropin-Releasing Hormone in the hypothalamus.
  • —Fertility Models: Preclinical investigation into reversing hypogonadotropic hypogonadism.
  • —Sex Steroid Feedback: Measuring the secondary production of testosterone and estrogen in animal models.
  • —Oncology Research: Investigating the KISS1 gene's original discovery as a tumour metastasis suppressor (metastin).
Published Research and Study Findings

Kisspeptin-10 revolutionized reproductive biology when researchers discovered that mutations in its receptor (GPR54) caused an absence of puberty in animal models and humans. Laboratory studies demonstrate that administering Kisspeptin-10 potently stimulates the HPG axis, resulting in a robust, dose-dependent release of LH and FSH. Unlike direct LH or FSH analogues, Kisspeptin-10 acts at the top of the endocrine cascade.

This makes it an invaluable research model for studying natural hormone feedback loops, as it relies on the body's endogenous GnRH neurons to function. Furthermore, because the KISS1 gene was originally identified for its ability to suppress melanoma metastasis, the peptide remains a significant focus in oncology research exploring how GPR54 activation limits the spread of certain cancer cells.

NoteAll findings are derived from laboratory and non-clinical research settings.
Representative Scientific References
  • 1.Seminara, S.B. et al., "The GPR54 gene as a regulator of puberty," New England Journal of Medicine, 2003.
  • 2.Dhillo, W.S. et al., "Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males," The Journal of Clinical Endocrinology and Metabolism, 2005.
  • 3.Gottsch, M.L. et al., "A role for kisspeptins in the regulation of gonadotropin secretion in the mouse," Endocrinology, 2004.
  • 4.Ohtaki, T. et al., "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor," Nature, 2001.
Technical data
Specifications
Purity
≥99%, HPLC verified
Form
Lyophilised white powder
Molecular formula
C63H83N17O14
Molecular weight
1302.4 g/mol
Sequence
Decapeptide
SKU
SHP-KISS10-005
Research category
Cognitive
Storage
-20°C, protected from light
Reconstitution
Reconstitute with bacteriostatic water; swirl gently, do not shake
Research use
In-vitro laboratory research only. Not for human consumption.
Common questions
Frequently asked questions
Kisspeptin-10 is a synthetic decapeptide and the primary endogenous ligand for the GPR54 (KISS1R) receptor. It is supplied lyophilised at ≥99% purity verified by HPLC and MS.
It is studied for hypothalamic-pituitary-gonadal axis modulation, GnRH pulsatility, fertility models, sex steroid feedback measurement and tumour metastasis suppression in oncology research.
Kisspeptin-10 is supplied at ≥99% purity, verified by HPLC with mass-spectrometry identity confirmation. Testing is carried out per batch rather than per product line, so the figures on your certificate of analysis relate to the exact lot in your vial.
Store the sealed vial at -20°C, protected from light. Once reconstituted, the solution should be kept refrigerated at 2-8°C, protected from light, and treated as a short-lived working preparation rather than a long-term stock.
Kisspeptin-10 is supplied lyophilised. Reconstitute with bacteriostatic water; swirl gently, do not shake, and allow the powder to dissolve fully before use. Direct the solvent down the inside wall of the vial rather than onto the pellet, and record the volume used so working concentrations can be calculated. This applies to in-vitro laboratory work only.
Both are used to study neuroendocrine axes, but different ones. Kisspeptin-10 acts through GPR54 at the top of the hypothalamic-pituitary-gonadal axis. ACTH (1-39) acts at the melanocortin 2 receptor on the adrenal cortex within the hypothalamic-pituitary-adrenal axis.
Yes. A certificate of analysis covering HPLC purity and mass-spectrometry identity is available for every batch of Kisspeptin-10. Each vial carries a batch number on its label, and quoting that number lets us send you the certificate that matches the material you hold rather than a generic example.
Kisspeptin-10 has the molecular formula C63H83N17O14 and a molecular weight of 1302.4 g/mol. Those figures are stated on the certificate of analysis supplied with each batch and are the values researchers use when preparing molar calculations.
Kisspeptin-10 ships from the UK to UK research addresses, with tracked dispatch and insulated packaging. It is sold for in-vitro laboratory research only: it is not a medicine, not a supplement, and not for human or veterinary consumption. Orders are accepted on the basis that the buyer is a qualified researcher.