Cortagen from Super Human Peptides UK is a highly targeted, synthetic tetrapeptide (sequence: Ala-Glu-Asp-Pro). It belongs to the advanced class of short peptide bioregulators developed by the St. Petersburg Institute of Bioregulation and Gerontology.
In laboratory research, Cortagen serves as a premier model for investigating profound neurorestoration and the reversal of age-related cognitive decline. Researchers utilize this peptide because it acts as an epigenetic switch specifically for the cerebral cortex and central nervous system. By penetrating the nucleus of neurons and interacting directly with DNA promoter regions, Cortagen stimulates the regeneration of nerve fibers and the up-regulation of vital neurotrophic factors.
Produced under GMP-compliant conditions and verified for 99% purity or higher, Cortagen is an essential tool for advanced in-vitro and in-vivo research into ischemic stroke recovery, traumatic brain injury (TBI), and neurodegenerative disease models.
- —Cerebral Bioregulator: A short, 4-amino-acid peptide that acts as an epigenetic switch specifically for brain tissue.
- —Neurogenesis: Stimulates the structural repair and regeneration of damaged peripheral and central nerve fibers.
- —Ischemic Protection: Protects neurons from hypoxia (oxygen deprivation) and subsequent necrotic cell death.
- —Epigenetic Action: Directly modulates gene expression to restore youthful function to aged or damaged cortical neurons.
- —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
- —Quality Standard: GMP / ISO certified manufacturing.
- —Ischemic Stroke Recovery: Preclinical models investigating the rapid salvage of cortical neurons and the reduction of infarct size following severe blood flow restriction.
- —Nerve Fiber Regeneration: Studying the physical regrowth and re-myelination of damaged nerve tissue in both the central and peripheral nervous systems.
- —Antioxidant Enzyme Activation: Measuring the peptide's ability to trigger the endogenous production of antioxidant enzymes (like superoxide dismutase) to combat oxidative stress in the brain.
- —Epigenetic Gene Regulation: Investigating the intracellular signaling pathways that allow the tetrapeptide to un-silence dormant DNA regions responsible for cellular repair.
- —Cognitive and Motor Restoration: Evaluating the reversal of age-related cognitive deficits and the rapid recovery of motor function following induced brain trauma.
Cortagen was developed as a synthetic analogue of Cortexin, a naturally occurring polypeptide complex extracted from the cerebral cortex of young animals. Through the pioneering research of Dr. Vladimir Khavinson, scientists identified the exact four-amino-acid sequence responsible for the profound neuroprotective effects observed with Cortexin.
Laboratory studies utilizing Cortagen demonstrate a highly specific, tissue-directed mechanism. In animal models of severe ischemic stroke, Cortagen administration significantly halted the spread of neuronal death and rapidly restored normal electroencephalogram (EEG) patterns. Furthermore, in vitro studies on aged neuronal cultures showed that Cortagen induces structural remodeling, promoting the outgrowth of neurites and stabilizing the cellular cytoskeleton.
Because it repairs the root epigenetic machinery of the brain rather than acting as a temporary central nervous system stimulant, it is a cornerstone compound in modern gerontology and neurobiology.
- 1.Khavinson, V.H. et al., "Peptide bioregulators: A new class of geroprotectors," Annals of the New York Academy of Sciences, 2002.
- 2.Chalisova, N.I. et al., "Effect of the Cortagen peptide on the regeneration of the nerve tissue," Neuroscience and Behavioral Physiology, 2006.
- 3.Khavinson, V.H. et al., "Epigenetic regulation of gene expression by peptide bioregulators," Biogerontology, 2006.
- 4.Mendzheritskii, A.M. et al., "Effect of cortagen on lipid peroxidation and antioxidant enzyme activity in rat brain during focal ischemia," Bulletin of Experimental Biology and Medicine, 2005.
