Sermorelin Acetate
Sermorelin Acetate

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Sermorelin Acetate

Sermorelin Acetate
Sermorelin Acetate
Sermorelin Acetate
Sermorelin Acetate
Sermorelin Acetate
Sermorelin Acetate

Sermorelin Acetate

£19.00Sold out
Out of stock
Size
1
ABOUT THIS COMPOUND
Description

Sermorelin Acetate from Super Human Peptides UK is a synthetic, 29-amino acid peptide. It represents the shortest fully functional fragment of naturally occurring endogenous Growth Hormone-Releasing Hormone (GHRH 1-29). In laboratory research, Sermorelin is utilized to study the direct stimulation of the pituitary gland to secrete growth hormone.

Unlike synthetic growth hormone, which shuts down the body's natural production, researchers use Sermorelin to investigate natural, pulsatile GH release that remains subject to the body's endogenous negative feedback loop (regulated by somatostatin). Produced under GMP-compliant conditions and verified for 99% purity or higher, Sermorelin Acetate is a foundational model for neuroendocrine research, anti-aging studies, and the exploration of the somatotropic axis.

WarningFor laboratory research use only. Not for human consumption.
Key Features
  • —GHRH Analogue: The active 1-29 amino acid sequence of natural Growth Hormone-Releasing Hormone.
  • —Natural Feedback Loop: Stimulates GH release without overriding the body's natural somatostatin regulation.
  • —Synergistic Potential: Frequently studied in combination with GHRPs (like Ipamorelin or GHRP-6) to observe amplified somatotropic effects.
  • —High Purity: 99% purity or higher (verified by HPLC and MS analysis).
  • —Quality Standard: GMP / ISO certified manufacturing.
Research Focus
  • —Pituitary Stimulation: Studying the binding affinity to GHRH receptors on pituitary somatotrophs.
  • —Somatostatin Regulation: Researching how the body naturally limits excessive GH release via negative feedback mechanisms.
  • —Synergistic Endocrine Models: Preclinical investigation of co-administering a GHRH (Sermorelin) with a GHRP (Ipamorelin) to measure exponentially increased hormone pulses.
  • —Circadian Rhythm and Sleep: Investigating the peptide's influence on promoting slow-wave (deep) sleep in animal models.
  • —Age-Related Endocrine Decline: Preclinical models exploring the restoration of youthful growth hormone levels in aged subjects.
Published Research and Study Findings

Sermorelin was developed after researchers discovered that only the first 29 amino acids of the naturally occurring 44-amino acid GHRH molecule were required to stimulate the pituitary gland effectively. Laboratory and clinical literature from the 1980s and 1990s extensively documented Sermorelin's safety profile, noting that because it works upstream—prompting the body to produce its own hormone—it does not cause the severe side effects (like organomegaly or severe insulin resistance) associated with direct recombinant human growth hormone administration. Today, it remains a primary research tool for studying the reversal of age-related somatopause (the natural decline in growth hormone) and is heavily featured in protocols investigating bone density, skin thickness, and lean muscle retention in aging models.

NoteAll findings are derived from laboratory and non-clinical research settings.
Representative Scientific References
  • 1.Thorner, M.O. et al., "Extrahypothalamic growth-hormone-releasing factor (GRF) stimulates growth hormone secretion in normal subjects," The Journal of Clinical Endocrinology & Metabolism, 1983.
  • 2.Vance, M.L. et al., "Growth hormone-releasing hormone: clinical studies and therapeutic aspects," Journal of the American Geriatrics Society, 1985.
  • 3.Prakash, A. et al., "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency," BioDrugs, 1999.
  • 4.Walker, R.F. et al., "Sermorelin: a review of its therapeutic use in the treatment of aging," Clinical Interventions in Aging, 2006.
Technical data
Specifications
Purity
≥99%, HPLC verified
Form
Lyophilised white powder
Molecular formula
C149H246N44O42S
Molecular weight
3357.9 g/mol
Sequence
GHRH (1-29) fragment, 29 amino acids
SKU
SHP-SERM-002
Research category
Secretagogues
Storage
-20°C, protected from light
Reconstitution
Reconstitute with bacteriostatic water; swirl gently, do not shake
Research use
In-vitro laboratory research only. Not for human consumption.
Common questions
Frequently asked questions
Sermorelin Acetate is a synthetic 29-amino-acid peptide representing GHRH 1-29, the shortest fully functional fragment of endogenous growth hormone-releasing hormone. It is supplied lyophilised at ≥99% purity.
It is used to investigate pituitary stimulation of growth hormone secretion in models where somatostatin feedback regulation is to be preserved, and as a baseline GHRH comparator against longer-acting analogues.
Sermorelin Acetate is supplied at ≥99% purity, verified by HPLC with mass-spectrometry identity confirmation. Testing is carried out per batch rather than per product line, so the figures on your certificate of analysis relate to the exact lot in your vial.
Store the sealed vial at -20°C, protected from light. Once reconstituted, the solution should be kept refrigerated at 2-8°C, protected from light, and treated as a short-lived working preparation rather than a long-term stock.
Sermorelin Acetate is supplied lyophilised. Reconstitute with bacteriostatic water; swirl gently, do not shake, and allow the powder to dissolve fully before use. Direct the solvent down the inside wall of the vial rather than onto the pellet, and record the volume used so working concentrations can be calculated. This applies to in-vitro laboratory work only.
Both act at the GHRH receptor. Sermorelin is the unmodified 1-29 fragment and is cleared quickly; CJC-1295 (NO DAC) carries four amino acid substitutions that shield it from DPP-4 and extend its active window to roughly 30 minutes. Researchers choose Sermorelin for the native reference profile and CJC-1295 where a longer signal is needed.
Yes. A certificate of analysis covering HPLC purity and mass-spectrometry identity is available for every batch of Sermorelin Acetate. Each vial carries a batch number on its label, and quoting that number lets us send you the certificate that matches the material you hold rather than a generic example.
Sermorelin Acetate has the molecular formula C149H246N44O42S and a molecular weight of 3357.9 g/mol. Those figures are stated on the certificate of analysis supplied with each batch and are the values researchers use when preparing molar calculations.
Sermorelin Acetate ships from the UK to UK research addresses, with tracked dispatch and insulated packaging. It is sold for in-vitro laboratory research only: it is not a medicine, not a supplement, and not for human or veterinary consumption. Orders are accepted on the basis that the buyer is a qualified researcher.