Dermorphin
Dermorphin

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Dermorphin

Dermorphin
Dermorphin
Dermorphin
Dermorphin
Dermorphin
Dermorphin

Dermorphin

£22.00Sold out
Out of stock
Size
1
ABOUT THIS COMPOUND
Description

Dermorphin from Super Human Peptides UK is a natural heptapeptide originally isolated from the skin of South American frogs (Phyllomedusa genus). It is a highly potent and selective Mu-opioid receptor agonist. In laboratory research, Dermorphin is utilized as a standard model for examining opioid receptor binding kinetics, pain-signalling modulation, and the physiological effects of potent peptide-based analgesics.

Its unique structure, containing a D-amino acid (D-Alanine), makes it highly resistant to metabolic degradation, providing researchers with a stable tool for long-duration in-vitro and in-vivo studies. Produced under GMP-compliant conditions and verified for 99% purity or higher, Dermorphin is intended strictly for controlled laboratory investigations.

WarningFor laboratory research use only. Not for human consumption.
Key Features
  • —High Selectivity: Targeted Mu-opioid receptor agonist.
  • —Maximum Purity: 99% purity or higher (verified by HPLC and MS analysis).
  • —Metabolic Stability: Natural D-Alanine inclusion for increased resistance to proteolysis.
  • —Quality Standard: GMP / ISO certified manufacturing.
Research Focus
  • —Opioid Receptor Kinetics: Selective binding and activation of the Mu-opioid receptor.
  • —Analgesic Mechanism Studies: Research into peptide-driven pain modulation.
  • —Blood-Brain Barrier (BBB) Permeability: Studies on peptide transport across biological membranes.
  • —Respiratory and Cardiovascular Impact: Preclinical modeling of opioid-induced physiological responses.
  • —Metabolic Resistance: Investigation of D-amino acid influence on peptide longevity.
Published Research and Study Findings

Dermorphin has been extensively studied for its superior potency compared to morphine and other endogenous opioid peptides like enkephalins. Research indicates that its high affinity for the Mu-receptor is attributed to its specific 7-amino acid sequence, specifically the presence of D-Ala in the second position. Laboratory models utilize Dermorphin to study the decoupling of analgesic effects from respiratory depression and potential tolerance mechanisms.

It remains one of the most cited peptides for exploring the pharmacodynamics of the opioid system in animal models.

NoteAll research applications are limited to controlled laboratory and preclinical settings.
Representative Scientific References
  • 1.Monteiro-Siqueira, M. et al., "Dermorphin: A potent Mu-opioid receptor agonist," Journal of Peptide Science, 2012.
  • 2.Negri, L. et al., "Pharmacological profile of dermorphin and its analogues," British Journal of Pharmacology, 1991.
  • 3.Amiche, M. et al., "The Dermorphin family: Structure-activity relationship studies," European Journal of Biochemistry, 1998.
  • 4.Broccardo, M. et al., "Relative potency of dermorphin on opioid receptors," British Journal of Pharmacology, 1981.
Technical data
Specifications
Purity
≥99%, HPLC verified
Form
Lyophilised white powder
Molecular formula
C40H50N8O10
Molecular weight
802.9 g/mol
Sequence
Heptapeptide containing D-alanine
SKU
SHP-DERMO-005
Research category
Cognitive
Storage
-20°C, protected from light
Reconstitution
Reconstitute with bacteriostatic water; swirl gently, do not shake
Research use
In-vitro laboratory research only. Not for human consumption.
Common questions
Frequently asked questions
Dermorphin is a natural heptapeptide originally isolated from Phyllomedusa frog skin, acting as a selective mu-opioid receptor agonist. Its D-alanine content confers resistance to metabolic degradation.
It is studied for opioid receptor binding kinetics, analgesic mechanism research, blood-brain barrier permeability and metabolic resistance in peptide design.
Dermorphin is supplied at ≥99% purity, verified by HPLC with mass-spectrometry identity confirmation. Testing is carried out per batch rather than per product line, so the figures on your certificate of analysis relate to the exact lot in your vial.
Store the sealed vial at -20°C, protected from light. Once reconstituted, the solution should be kept refrigerated at 2-8°C, protected from light, and treated as a short-lived working preparation rather than a long-term stock.
Dermorphin is supplied lyophilised. Reconstitute with bacteriostatic water; swirl gently, do not shake, and allow the powder to dissolve fully before use. Direct the solvent down the inside wall of the vial rather than onto the pellet, and record the volume used so working concentrations can be calculated. This applies to in-vitro laboratory work only.
Dermorphin acts directly at the mu-opioid receptor, which places it in classical opioid receptor pharmacology. ARA-290 works through the Innate Repair Receptor and is studied in neuropathic pain and small fibre neuropathy models, a non-opioid route to the same broad research area.
Yes. A certificate of analysis covering HPLC purity and mass-spectrometry identity is available for every batch of Dermorphin. Each vial carries a batch number on its label, and quoting that number lets us send you the certificate that matches the material you hold rather than a generic example.
Dermorphin has the molecular formula C40H50N8O10 and a molecular weight of 802.9 g/mol. Those figures are stated on the certificate of analysis supplied with each batch and are the values researchers use when preparing molar calculations.
Dermorphin ships from the UK to UK research addresses, with tracked dispatch and insulated packaging. It is sold for in-vitro laboratory research only: it is not a medicine, not a supplement, and not for human or veterinary consumption. Orders are accepted on the basis that the buyer is a qualified researcher.